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The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

"In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.

Bender, Ph D, of National Jewish Medical and Research Center in Denver.

"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.

This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.

Patients who experience significant allergic symptoms regularly may take daily antihistamines to keep their symptoms under control.

Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.

Desloratadine inhibited histamine release from human mast cells in vitro.

Many different brands and forms of oral antihistamines are available over the counter (OTC).

Oral antihistamines are available as pills, chewable tablets, orally disintegrating tablets, capsules, and liquid.




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